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This page contains answers to common questions about rheumatic conditions and treatment. If you need further assistance please phone our advice line on 01473 703315. As there are a large number of questions on this page you may need to scroll down to see them all.

Rheumatology FAQs

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Why do I need to take folic acid after methotrexate each week?

Methotrexate is antagonistic to folate, which is necessary for the production of red and white blood cells. A synthetic form of folate – folic acid - is usually given to counteract this, usually as a single 5mg tablet to be taken 24 hours after your methotrexate each week. This can minimise side effects from methotrexate such as nausea or mouth ulcers. If these are severe you may be advised to take folic acid more frequently, perhaps several times per week.